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Exosomes engineered with SARS-CoV-2 spike and nucleocapsid proteins induce strong immune response against multiple variants of concern (VOCs)

Justin B Nice, Mafalda Cacciottolo, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun 

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Exosome-Based Multivalent Vaccine: Achieving Potent Immunization, Broadened Reactivity, and Strong T-Cell Responses with Nanograms of Proteins

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Multivalent Exosome based vaccine: a “cocktail” approach to epidemic viruses’ challenges

Mafalda Cacciottolo, LiEn Hsieh, Yujia Li, Justin B Nice, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins.

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome-mediated mRNA Delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai, Nadia A. Atai, Mafalda Cacciottolo, Justin Nice, Arjang Salehi, Chenxu Guo, Alanna Sedgwick, Saravana Kanagavelu, Stephen J. Gould

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Extracellular Vesicles Derived from Cardiosphere-derived Cells as a Potential Antishock Therapeutic

Chance, Tiffani C. PhD; Wu, Xiaowu MD; Keesee, Jeffrey D. BS; Garcia-Marcano, Josue; Salgado, Christi L. BS; Liu, Bin BS; Moseley, Jennifer J. PhD; Peck, Kiel A. MS; R.-Borlado, Luis PhD; Atai, Nadia A. MD, PhD; Gould, Stephen J. PhD; Marban, Linda S. PhD; Cap, Andrew P. MD, PhD; Rathbone, Christopher R. PhD; Bynum, James A. PhD

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Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1

Ahmed Gamal-EldinIbrahim Ph.D., MPH, Chang Li BS, Alessandra Ciullo Ph.D. K. Candis Jones-Ungerleider MD, MSE, Kiel Peck BS, Linda Marbán Ph.D, Eduardo Marbán MD, Ph.D

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The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

Chenxu Guo, Shang-Jui Tsai, Yiwei Ai, Maggie Li, Andrew Pekosz, Andrea Cox, Nadia Atai, Stephen J. Gould

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Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

Ahmed G. E. Ibrahim, Chang Li, Russel Rogers, Mario Fournier, Liang Li, Sharon D. Vaturi, Travis Antes, Lizbeth Sanchez, Akbarshakh Akhmerov, Jennifer Johnson Moseley, Brooke Tobin, Luis Rodriguez-Borlado, Rachel R. Smith, Linda Marbán & Eduardo Marbán

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