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Potency Assay Development for CAP-1002: An Allogeneic Cell Therapy in Phase 3 Clinical Trial for DMD

Minghao Sun, Kristi Elliott, Yujia Li, Lena Trinh, Firouz Mohsenian, Priya Mistry, Meena Murali, Stephanie Adachi, Esther Chin, Ben Canter, Arjang Salehi, Priyanka Ghorpade

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Exosomes engineered with SARS-CoV-2 spike and nucleocapsid proteins induce strong immune response against multiple variants of concern (VOCs)

Justin B Nice, Mafalda Cacciottolo, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun 

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Exosome-Based Multivalent Vaccine: Achieving Potent Immunization, Broadened Reactivity, and Strong T-Cell Responses with Nanograms of Proteins

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Multivalent Exosome based vaccine: a “cocktail” approach to epidemic viruses’ challenges

Mafalda Cacciottolo, LiEn Hsieh, Yujia Li, Justin B Nice, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins.

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomized, double-blind, placebo-controlled, phase 2 trial

Craig M McDonald, Eduardo Marbán, Suzanne Hendrix, Nathaniel Hogan, Rachel Ruckdeschel Smith, Michelle Eagle, Richard S Finkel, Cuixia Tian, Joanne Janas, Matthew M Harmelink, Arun S Varadhachary, Michael D Taylor, Kan N Hor, Oscar H Mayer, Erik K Henricson, Pat Furlong, Deborah D Ascheim, Siegfried Rogy, Paula Williams, Linda Marbán, with the HOPE-2 Study Group

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Exosome-mediated mRNA Delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai, Nadia A. Atai, Mafalda Cacciottolo, Justin Nice, Arjang Salehi, Chenxu Guo, Alanna Sedgwick, Saravana Kanagavelu, Stephen J. Gould

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Extracellular Vesicles Derived from Cardiosphere-derived Cells as a Potential Antishock Therapeutic

Chance, Tiffani C. PhD; Wu, Xiaowu MD; Keesee, Jeffrey D. BS; Garcia-Marcano, Josue; Salgado, Christi L. BS; Liu, Bin BS; Moseley, Jennifer J. PhD; Peck, Kiel A. MS; R.-Borlado, Luis PhD; Atai, Nadia A. MD, PhD; Gould, Stephen J. PhD; Marban, Linda S. PhD; Cap, Andrew P. MD, PhD; Rathbone, Christopher R. PhD; Bynum, James A. PhD

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Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1

Ahmed Gamal-EldinIbrahim Ph.D., MPH, Chang Li BS, Alessandra Ciullo Ph.D. K. Candis Jones-Ungerleider MD, MSE, Kiel Peck BS, Linda Marbán Ph.D, Eduardo Marbán MD, Ph.D

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