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Exosome-mediated mRNA Delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai, Nadia A. Atai, Mafalda Cacciottolo, Justin Nice, Arjang Salehi, Chenxu Guo, Alanna Sedgwick, Saravana Kanagavelu, Stephen J. Gould

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Extracellular Vesicles Derived from Cardiosphere-derived Cells as a Potential Antishock Therapeutic

Chance, Tiffani C. PhD; Wu, Xiaowu MD; Keesee, Jeffrey D. BS; Garcia-Marcano, Josue; Salgado, Christi L. BS; Liu, Bin BS; Moseley, Jennifer J. PhD; Peck, Kiel A. MS; R.-Borlado, Luis PhD; Atai, Nadia A. MD, PhD; Gould, Stephen J. PhD; Marban, Linda S. PhD; Cap, Andrew P. MD, PhD; Rathbone, Christopher R. PhD; Bynum, James A. PhD

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Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1

Ahmed Gamal-EldinIbrahim Ph.D., MPH, Chang Li BS, Alessandra Ciullo Ph.D. K. Candis Jones-Ungerleider MD, MSE, Kiel Peck BS, Linda Marbán Ph.D, Eduardo Marbán MD, Ph.D

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The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

Chenxu Guo, Shang-Jui Tsai, Yiwei Ai, Maggie Li, Andrew Pekosz, Andrea Cox, Nadia Atai, Stephen J. Gould

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Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial

Raj R Makkar, Dean J Kereiakes, Frank Aguirre, Glenn Kowalchuk, Tarun Chakravarty, Konstantinos Malliaras, Gary S Francis, Thomas J Povsic, Richard Schatz, Jay H Traverse, Janice M Pogoda, Rachel R Smith, Linda Marbán, Deborah D Ascheim, Mohammad R Ostovaneh, João A C Lima, Anthony DeMaria, Eduardo Marbán, Timothy D Henry

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Allogeneic cardiosphere derived cells (CAP 1002) in critically ill COVID 19 patients: compassionate use case series

Siddharth Singh, Tarun Chakravarty, Peter Chen, Akbarshakh Akhmerov, Jeremy Falk, Oren Friedman, Tanzira Zaman, Joseph E. Ebinger, Mitch Gheorghiu · Linda Marbán, Eduardo Marbán, Raj R. Makkar

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MicroRNA composition delineates cardiosphere-derived cell and mesenchymal stem cell extracellular vesicles

Ann-Sophie Walravens, Sasha Smolgovsky, Liang Li, Lauren Kelly, Travis Antes, Kiel Peck, Tanner Quon, Linda Marbán, Benjamin Berman, Luis R. Borlado, Geoffrey de Couto

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Allogeneic Cardiosphere-derived Cells for the Treatment of Heart Failure with Reduced Ejection Fraction: Results of the Dilated cardiomyopathy iNtervention with Allogeneic Myocardially-regeneratIve Cells (DYNAMIC) trial

Chakravarty T, Henry TD, Kittleson M, Lima J, Siegel RJ, Slipczuk L, Pogoda JM, Smith RR, Malliaras K, Marbán L, Ascheim DD, Marbán E, Makkar RR.

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Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

Ahmed G. E. Ibrahim, Chang Li, Russel Rogers, Mario Fournier, Liang Li, Sharon D. Vaturi, Travis Antes, Lizbeth Sanchez, Akbarshakh Akhmerov, Jennifer Johnson Moseley, Brooke Tobin, Luis Rodriguez-Borlado, Rachel R. Smith, Linda Marbán & Eduardo Marbán

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Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice

Russell G. Rogers, Mario Fournier, Lizbeth Sanchez, Ahmed G. Ibrahim, Mark A. Aminzadeh, Michael I. Lewis, and Eduardo Marbán  

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